PTGS2 and colorectal adenoma: Genetically, the carriers of the COX-2 A-1195G AG genotype have 2 and 2.9 times increased risk of developing colorectal adenoma and cancer, respectively, while the respective risk of developing adenoma and CRC for COX-2 A-1195G AA genotype is 1.8 and 3.1 times lower than the general populace [11].