The Apelin signaling pathway, alcoholism, viral carcinogenesis, nicotinate and nicotinamide metabolism, microRNAs in cancer, human papillomavirus infection, Notch signaling pathway, longevity regulating pathway‐multiple species, cell cycle, and apoptosis were the primary signaling pathways that were impacted by the 57 relevant signaling pathways that were found to be expressed by KEGG enrichment analysis (Table S7, Figure 7C). Here, APLN is linked to alcohol dependence.