In this regard, increased plasma concentrations of several angiogenic mediators, including angiopoietin 2, TEK tyrosine kinase endothelial (Tie2), intercellular adhesion molecule 3 (ICAM3), and vascular cell adhesion molecule 1 (VCAM1), are increased in patients with HPS and cirrhosis.11 This evidence concerns the gene ICAM3 and Hermansky-Pudlak syndrome.