Second, tumor subsets enriched for microenvironment features, including hypoxia markers (e.g., Slc2a1, Pdk1, Car9), extracellular matrix (ECM) genes (e.g., Matn2, Fn1, Dcn, Col6a1), vasculature (e.g., Cdh5, Pecam1, Vwf), and interferon response genes (e.g., Rsad2, Ifit3, Gbp3, Cxcl10, Cd274). Here, CDH5 is linked to neoplasm.