Second, tumor subsets enriched for microenvironment features, including hypoxia markers (e.g., Slc2a1, Pdk1, Car9), extracellular matrix (ECM) genes (e.g., Matn2, Fn1, Dcn, Col6a1), vasculature (e.g., Cdh5, Pecam1, Vwf), and interferon response genes (e.g., Rsad2, Ifit3, Gbp3, Cxcl10, Cd274). Here, COL6A1 is linked to neoplasm.