Second, tumor subsets enriched for microenvironment features, including hypoxia markers (e.g., Slc2a1, Pdk1, Car9), extracellular matrix (ECM) genes (e.g., Matn2, Fn1, Dcn, Col6a1), vasculature (e.g., Cdh5, Pecam1, Vwf), and interferon response genes (e.g., Rsad2, Ifit3, Gbp3, Cxcl10, Cd274). This evidence concerns the gene CD274 and neoplasm.