In high-fat diet/streptozotocin (HFD/STZ)-induced mice, PCSK9 mAbs inhibited the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway associated with inflammation cascades and markedly reduced the Scr, BUN, and UACR indexes in DKD (52). The gene discussed is CGAS; the disease is diabetic kidney disease.