reported that the insulin-regulated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway was activated in db/db mice with the long-term administration of atorvastatin or rosuvastatin, which may increase insulin resistance, interfere with lipid metabolism, and lead to inflammation and fibrosis, ultimately exacerbating diabetic nephropathy progression (35). This evidence concerns the gene INS and diabetic kidney disease.