NAGLU and mucopolysaccharidosis type 3B: The observed increase in iron content in the total brain of adult MPSIIIB mice aligns with our previous study showing increased iron content in the parietal cortex of MPSIIIB mice and with data from patients evidencing iron deposits in specific region of brain by MRI (Brady et al., 2013), reinforcing the notion that iron dysregulation is a significant feature of MPSIIIB disorder.