FUS and amyotrophic lateral sclerosis: Cha et al. (2023) found that knocking down the GSTO2 gene in fruit flies leads to an age-related increase in Cabeza protein levels in neurons. Cabeza, a homolog of the human FUS protein associated with degenerative CNS diseases like ALS and Frontotemporal Dementia, shows increased mislocalization and aggregation in the cytoplasm of neurons and reduced solubility in aging neurons when GSTO2 is knocked out. This suggests GSTO2 plays a crucial role in regulating Cabeza localization and aggregation, potentially impacting neurodegenerative disease development (Machamer et al., 2018).