Ongoing research has identified several risk factors and biomarkers associated with complicated AA in children, such as delayed presentation, symptom duration exceeding 24 h, age under 5 years, the presence of an appendicolith, elevated leukocyte counts, hyponatremia, increased procalcitonin levels, and high C-reactive protein (CRP) levels [6, 7, 9, 10]. This evidence concerns the gene CRP and Hyponatremia.