Among them, SQSTM1 p.His359del is recorded in the ClinVar database, classified as a variant of uncertain significance for frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTD-ALS1) and Paget disease of bone 2, early-onset (PDB2). This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.