In the Chinese ALS population, the most prevalent mutation causing ALS is located in the SOD1 gene, representing around 21.9% of familial cases and 1.90% of sporadic cases, followed by FUS and TARDBP, accounting for 6.3 and 3.1% of FALS patients, respectively (2). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.