Studies have exhibited that biomarkers such as brain-specific proteins (neuron-specific enolase [NSE], S100B, ubiquitin carboxy-terminal hydrolase-L1, and total Tau) and cytokines (tumor necrosis factor alpha, interferon-gamma, IL-6, IL-1β, IL-10, IL-13, and brain-derived neurotrophic factor) are helpful for diagnosing HIE and predicting neurodevelopmental outcomes (25–28). This evidence concerns the gene ENO2 and perinatal asphyxia.