The high expression of five ferroptosis-related genes (such as ACSL1 and CREB5) in monocytes of COVID-19 patients may affect the inflammatory response, which could further influence the development of stroke, particularly in strokes triggered by COVID-19 infection (50, 51).Targeted ferroptosis may serve as a potential therapeutic approach for managing excessive inflammation induced by coronavirus infection (52). Here, CREB5 is linked to stroke disorder.