Interestingly, the patient harboring a variant in the same residue (c.172C>T, p. (Pro58Ser)) who has recurrent infections, bronchiectasis, reduced CD132 expression, and impaired STAT5 phosphorylation with IL-2 and IL-21, but normal Ig levels and conserved antibody levels to pneumococcus and tetanus, presented an expansion of γδ T cells (18). The gene discussed is IL21; the disease is tetanus.