For example, miR-218 can target LGR4 to reduce AKT levels in PCa cells, target RICTOR to inhibit the phosphorylation of AKT at Ser473, and target GAB2 to disrupt the coexistence environment of PI3K and PIPs to inhibit the PAM signaling pathway (46–48). This evidence concerns the gene PIK3CD and posterior cortical atrophy.