Dysregulation of EGFR promotes the progression of PCa to bone metastasis (79), and both LINC00963 and the lncRNA RHPN1-AS can contribute to the overexpression of the EGFR gene and increase the migration and invasion of PCa cells; these effects may be mediated via the PAM pathway (12, 23). This evidence concerns the gene RHPN1 and posterior cortical atrophy.