The mutation of LRP1B has been identified in various cancers, including hepatocellular carcinoma (HCC) (7), ovarian cancer (OC) (49), glioblastoma (GB) (50), Merkel cell carcinoma (51), and gastric cancer (GC) (52), and is speculated to play a negative regulatory role in cancers. The gene discussed is LRP1B; the disease is Merkel cell skin cancer.