CD4 and infection: Concurrently, as the infection persisted, the correlation coefficient between macrophages' methylation profile and the uninfected samples gradually increased (D1–D0, r = 0.92; D7–D0, r = 0.93; D14–D0, r = 0.94; All p < 0.001), while the correlation coefficient between CD4+ T cell methylation profile and uninfected samples decreased (D1–D0, r = 0.97; D7–D0, r = 0.93; D14–D0, r = 0.92; All p < 0.001) (Figure 1F).