Another intriguing example is HDAC4, which may deacetylate hypoxia inducible factor 1 subunit alpha (HIF‐1α) that upregulates vascular endothelial growth factor A (VEGFA), which consequently leads to suppression in osteogenic precursor cells differentiation and aggravate diabetic OP in mice [98]. The gene discussed is VEGFA; the disease is diabetes mellitus.