[164] show that concerning type II diabetes‐induced OP, SENP3‐mediated de‐SUMOylation of SUMO2/3 on HIF‐1α stabilizes HIF‐1α, leading to potentiation of PPAR‐γ transcription that causes osteoclastogenesis suppression in BMMs. Here, HIF1A is linked to type 2 diabetes mellitus.