The role of astrocytes in epilepsy has been extensively investigated, with evidence indicating that astrocyte reactivity, as demonstrated by increased GFAP expression, contributes to neural hyperexcitability in several brain regions, including the hippocampus and thalamus, during chronic temporal lobe epilepsy (TLE) (Garzillo and Mello, 2002; Zhang et al., 2015). This evidence concerns the gene GFAP and epilepsy.