Among these, pathways such as Lipid and atherosclerosis (hsa05417), the PI3K-Akt signaling pathway (hsa04151), and the AGE-RAGE signaling pathway in diabetic complications (hsa04933) were enriched by five key target genes (MAPK1, MAPK3, AKT1, PIK3R1, IL6). The gene discussed is MAPK3; the disease is atherosclerosis.