INS and Insulin resistance: In contrast, the Met, HLB-H, and HLB-L treatment groups showed significantly lower INS and IR levels and significantly higher ISI values (p < 0.001 for Met, p < 0.05 and p < 0.001 for HLB-H, p < 0.05 and p < 0.001 for HLB-L), suggesting that HLB effectively enhances insulin sensitivity and ameliorates insulin resistance in the context of T2DM (Figures 1A–C).