Commonly, the transcription factor SOX1 is downregulated in cancer due to promoter hypermethylation [96, 97, 98], however, the inhibition of SOX1 in glioma stem cells has been found to decrease proliferation in vitro [96], while overexpression of SOX1 suppresses invasion and growth in lung cancer [98]. This evidence concerns the gene SOX1 and central nervous system cancer.