The underlying mechanisms of ANKRD26 mutation-associated thrombocytopenia remain largely unexplored, apart from evidence suggesting overactivation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway in in vitro-cultured megakaryocytes from patients with THC2 (Bluteau et al., 2014). Here, WNK2 is linked to Thrombocytopenia.