Severe thrombocytopenia, defined by total thrombocyte count <15×109/l, occurred in 45.4% and 63.6% of ankrd26ku6/+;adamts13−/− and ankrd26ku6;adamts13−/− zebrafish, respectively, compared to 0% of the wt or ankrd26ku6/+ zebrafish (Fig. 7A). This evidence concerns the gene ADAMTS13 and Thrombocytopenia.