These results demonstrated that the expression profiles of NKG2A and IL-2Rβγ in tumor-infiltrated CD8+ T and NK cells of mice were similar to that of NKG2A and IL-2Rβγ in intratumoral CD8+ T and NK cells of humans, suggesting the feasibility and translational significance of orchestrating CD8+ T and NK cells by NKG2A-targeted delivery of IL-2Rβγ agonist for tumor immunotherapy in mice. Here, CD8A is linked to neoplasm.