Figure 7(C,D) demonstrated that little change was observed in CD8+ Tcm and CD4+ Tcm within two weeks after rechallenge. However, both CD8+ Tem and CD4+ Tem cells were increased for 8.6 and 5.6 times (10.8 × 103 vs 77.9 × 103 cells/mL for CD8+ Tem, 4.7 × 103 vs 21.9 × 103 cells/mL for CD4+ Tem), respectively, after rechallenge of the mice for two weeks, indicating that αNKG2A-N215 treatment induced long-term immunological memory against tumor. Here, CD4 is linked to neoplasm.