Although the counts of CD8+ T cells (20.1 × 105 cells/gram) were significantly (P < 0.01) greater than those of NK cells (4.4 × 105 cells/gram) in tumor grafts treated with αNKG2A-N215 (Figure 5(E,F)), the increasing degree of NK cells (7.5 folds) was comparable to that of CD8+ T cells (8.1 folds), indicating that αNKG2A-N215 exerted antitumor effect by orchestrating both CD8+ T and NK cells in mice bearing MC38 tumor grafts. This evidence concerns the gene CD8A and neoplasm.