TNF and arthritic joint disease: Other forms of arthritis involve several proinflammatory cytokines that contribute to joint inflammation and cartilage and bone erosion, such as TNF-α, IL-1, IL-6, IL-17α, IL-12, granulocyte/macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFNγ), and vascular endothelial growth factor (VEGF) [18–20].