As an example, the Jcomp score across the 11 lung cancer tissues was positively correlated with the expression of genes coding MHC-class I protein (B2M, HLA-A, HLA-B, and HLA-C) (Additional file 1: Fig. S9), which are among the biomarkers for immunotherapy response [5]. The gene discussed is HLA-B; the disease is lung carcinoma.