We additionally showed that mice exposed to RT + IL-1αMPs generated an increase in CD8 + T cell and antigen-specific (HPV-E7) CD8 + T cell infiltration in non-irradiated (distal) tumors (compared to control, Fig. 5D,E) and the anti-tumor effect of RT + IL-1αMPs on distal tumors was CD8 + T cell dependent (Fig. 5I-L). This evidence concerns the gene CD8A and neoplasm.