The depletion of FOXP1 led to decreased mRNA and protein expression of N-cadherin and vimentin and increased expression of E-cadherin, underscoring the role of FOXP1 in regulating EMT and metastasis in chemoresistant pancreatic cancer (Figs. 3C and S3A). This evidence concerns the gene CDH1 and familial pancreatic carcinoma.