GAS2 and hearing loss disorder: GAS2 colocalizes with these microtubule bundles, and the variants (GAS2 c.723+1G>A; GAS2 c.616–2A>G) introduce a stop codon within the GAR domain (Fig. 1A bottom panel), resulting in disordered microtubule arrays and causing inherited hearing loss (Chen et al, 2021; Zhang et al, 2024).