To investigate whether FBXW7 participates in the STM2457-induced MCL1 degradation in AML, we used RNA interference and found that knockdown of FBXW7 slowed the degradation of MCL1 by STM2457 in Molm13 and THP-1 cells (Fig. 4K–N). This evidence concerns the gene FBXW7 and acute myeloid leukemia.