MCL1 and acute myeloid leukemia: In addition, the protein levels of MCL1 in AML cell lines showed a statistically significant negative correlation with the GI50 values of STM2457 (r = -0.684, P = 0.02), suggesting that MCL1 levels may serve as a potential biomarker for STM2457 efficacy in AML (Supplementary Fig. S4A–C).