NAP1L1 and Myocardial fibrosis: Nap1l1 p.D349E KI mice also showed more severe myocardial fibrosis (Supplementary Fig. S7E, F) Nap1l1 p.D349E KI mice exhibited worse cardiac function, including LVPW;d, LVPW;s, EF, FS (Supplementary Fig. S7G, H).