TLR4 and cancer: DAMPs derived from ferroptotic cancer cells, such as calreticulin (CRT), high-mobility group box 1 (HMGB1), and ATP, can engage with surface receptors on dendritic cells (DCs) including CD91, toll-like receptor 4 (TLR4), and purinergic P2RX7 receptor, thereby promoting DC activation and maturation to subsequently activate CD8+T cells [31–34].