NMNAT1 and neoplasm: Proteins such as Nicotinamide nucleotide adenylyltransferase 1, which are highly expressed in tumor cells and involved in the assembly process of mitochondrial Iron-Sulfur Cluster, as well as calcium-independent phospholipase A2β (iPLA2β), can reduce the sensitivity of tumor cells to ferroptosis by decreasing the LIP and hydrolyzing peroxidized lipids, respectively, leading to the evasion of ferroptosis in tumor cells [52, 63].