Ferroptotic cancer cells can upregulate cyclooxygenase-2 (COX-2) expression and then elevate levels of its downstream product prostaglandin E2 (PGE2) [14], an important immune regulator capable of inhibiting chemokines CCL5 and XCL1 secreted by natural killer (NK) cells, consequently restricting cDC1 infiltration. The gene discussed is PTGS2; the disease is cancer.