In support with this postulation, serum magnesium was found to be positively correlated with PT, aPTT and HDL, and negatively correlated with PAI-1, HbA1c, triglycerides among the children and adolescents with T1DM, but not in controls which suggest its role in diabetic microangiopathy. The gene discussed is SERPINE1; the disease is type 1 diabetes mellitus.