VEGFA and neoplasm: Physical strategies include: (1) Radiotherapy: This increases vascular leakiness via upregulation of VEGF and FGF expression.293 (2) Hyperthermia: Using radiofrequency, microwave, and focused ultrasound-induced hyperthermia to increase the tumor blood flow and vascular permeability.294 (3) Ultrasonic wave: Including microbubble oscillation and implosion to increase vessel permeability.295