This, in turn, enables more effective delivery of oxygen and therapeutic agents to tumor cells and has become one of the promising strategies to enhance the efficacy of PDT.388 Strategies employing drugs to normalize vasculature can be categorized into three main types: (1) Traditional antiangiogenic drugs, such as the multi-kinase inhibitor (Regorafenib),389 the multi-targeted tyrosine kinase inhibitor (Lenvatinib),390 and the EGFR inhibitor (Erlotinib).391 For example, Wan et al. created a conjugated polymer delivery system combining a NIR-II excitable photosensitizer with regorafenib. Here, EGFR is linked to neoplasm.