A PS (IR780) and OXPHOS inhibitor (MET) were coloaded into an amphipathic nanocarrier, poly(ε-caprolactone)-poly (ethylene glycol) (PEG-PCL), to afford PEG-PCL-IR780-MET (P-P-I-M) nanoparticles.413 When the tumor was irradiated with an 808-nm laser for 1 min, the rapidly generated ROS disintegrated PEG-PCL to release MET and IR780. The gene discussed is MET; the disease is neoplasm.