STAT3 and neoplasm: Additionally, the capability of regorafenib to reprogram M2 phenotype TAMs into M1 phenotype TAMs amplifies the PDT-induced ICD and reverses the immunosuppressive tumor microenvironment.389 Furthermore, current research has developed a variety of therapeutic strategies targeting MDSCs, including targeted depletion, inhibition of functionality, and prevention of recruitment.563 For instance, Chen et al. utilized gemcitabine (GEM), which preferentially reduces the percentage of MDSCs without necessitating the selective blockade of the JAK/STAT3 pathway to eliminate other leukocytes.