NFE2L3 and nonpapillary renal cell carcinoma: To further determine the role of NFE2L3 in ccRCC, NFE2L3 knockdown cell lines were constructed (Fig. 6d, e), and we found that NFE2L3 knockdown significantly inhibited cell proliferation (Fig. 6f, g; Supplementary Fig. S3a, b) and migration (Fig. 6h; Supplementary Fig. S3c).