RP-6306 at 5 mg/kg or 10 mg/kg with RP-3500 (5 mg/kg) resulted in significant tumor regressions compared to RP-6306 monotherapy at 10 mg/kg (P = 0.0240, P = 0.0025, respectively) and RP-3500 monotherapy in the CCNE1 amp EMCA model (WU-115) model (P = 0.0032, P = 0.002, respectively, Fig. 3A and Supplementary Fig. S5A). This evidence concerns the gene CCNE1 and neoplasm.