Our results demonstrated that conditional knockout of C/EBPβ in VSMCs alleviated hyperlipidemia-induced arterial stiffness, as evidenced by an ameliorative increase in aPWV, an improvement in arterial diastolic function, reduction in vessel wall thickness, attenuated decrease in elastic fibers and alleviated increase in proteoglycans (Fig. 5d, f). This evidence concerns the gene CEBPB and hyperlipidemia.