ADIPOQ and Alzheimer disease: To examine the regulatory effects of KIAA1199 on AD differentiation, we firstly inhibited the expression of KIAA1199 by specific siRNAs in hBMSC, that reduced the KIAA1199 expression by more than 85% during 14 days of in vitro AD differentiation (Fig. S2a, b), and led to significantly impaired AD differentiation, evidenced by fewer lipid-filled, Oil red O positive mature adipocytes and decreased expression levels of adipocyte specific genes: PPARG2, FABP4, ADIPOQ and LPL (Fig. 1a).