Moreover, using our previous genome-wide maps of enhancer activity data17 and chromatin interaction data,18 we found a progressive decreased H3K27-acetylation, mediator occupancy and connectivity with the downstream super-enhancer region to the KIAA1199 promoter region during AD differentiation (Fig. S1k), suggesting a inhibition of KIAA1199 during AD process. Here, CEMIP is linked to Alzheimer disease.