Taken together the molecular mechanism that we reported for KIAA1199 effects on bone formation and osteoblast (OB) differentiation,16 applies to fat formation and AD differentiation where the OPN/integrin signaling mediates the regulatory effects of KIAA1199 on lineage differentiation of hBMSC and involve down-stream effectors of AKT and ERK signaling pathways. Here, SPP1 is linked to Alzheimer disease.