CEMIP and osteoporosis: We have recently reported that KIAA1199 regulates bone formation during adult bone remodeling and its absence leads to increased bone mass and enhanced bone regeneration following bone fracture, and that it is expressed at a higher level in osteoporosis patients16 suggesting that the biological role of KIAA1199 extends beyond development to regulation of adult tissue homeostasis and its relevance to the pathophysiology of human aging.