Similar to the observations under normal diet, KIAA1199 KO mice under HFD exhibited reduced SAT and VAT, but not BAT (Fig. 4f) and histological analysis revealed smaller adipocytes in SAT, VAT and BAT (Fig. S12), as well as reduced expression levels of AD-specific genes (Fig. 4g and Fig. S13a). The gene discussed is CEMIP; the disease is Alzheimer disease.