SPP1 and Alzheimer disease: We have previously reported that osteopontin (OPN) is a KIAA1199 target gene16 and deficiency of KIAA1199 enhances osteoblast differentiation of hBMSC through induction of OPN expression.16 Similarly, we observed that impaired AD differentiation in KIAA1199 deficient hBMSC (siR-KIAA1199) was associated with higher expression levels of OPN during AD differentiation (Fig. S23a-d).