Interestingly, HFD induced hepatic steatosis in WT mice, which was significantly reduced in KIAA1199 KO as evidenced by lower liver weight and liver lipid accumulation (Fig. 5k and Fig. S16a–d), and associated with lower expression levels of both AD gene markers (Fig. 5l and Fig. S16e) and inflammatory gene markers (Fig. 5m and Fig. S16f) in livers. Here, CEMIP is linked to Alzheimer disease.