Some studies have reported a positive association between circulating levels of KIAA1199 and inflammatory diseases and clinical prognosis in several cancer types.11,13,35–42 We have observed that expression level of KIAA1199 is a possible biomarker for metabolic health as KIAA1199 tissue expression and/or plasma levels exhibit positive correlation with clinical characteristics of obesity and metabolic syndrome, which are characterized by the presence of a chronic low-grade inflammation. This evidence concerns the gene CEMIP and obesity due to melanocortin 4 receptor deficiency.