LRRK2 and Parkinson disease: Exploring the relationship between LRRK2 and microglia-mediated neuroinflammation is crucial for elucidating the function of LRRK2 in PD.Our research identified a marked upregulation of LRRK2 expression in BV2 microglial cells following stimulation with α-syn, with expression levels increasing in a dose- and time-dependent manner.