For example, mutations in the human RNPC3/65K are linked to hypopituitarism, growth hormone deficiency, and primary ovarian insufficiency (Argente et al. 2014; Norppa et al. 2018; Verberne et al. 2020; Akin et al. 2022; Bezen et al. 2022). This evidence concerns the gene RNPC3 and hypopituitarism.