RNPC3 and ovarian dysfunction: Human RNPC3 mutations have been associated with hypopituitarism, growth hormone deficiency, and primary ovarian insufficiency—conditions that involve early ovarian failure and infertility (Argente et al. 2014; Norppa et al. 2018; Verberne et al. 2020; Akin et al. 2022; Bezen et al. 2022).