Although Mdga2 +/− mice exhibit social deficits, increased repetitive behavior, and cognitive impairment, blocking the BDNF/TrkB signaling with ANA-12 and the MDGA2-P2 peptide and blocking AMPAR with CP-465022 only attenuated social deficits but not increased repetitive behavior or cognitive impairment in these mice. The gene discussed is NTRK2; the disease is Cognitive impairment.