Several recent studies also showed that MDGA2 negatively regulates glutamatergic synapse functions in cultured neurons [19] and that MDGA2 does not affect the abnormal cytosolic Gephyrin aggregation, the reduction in inhibitory synaptic transmission, or the increased anxiety-related behavior in Nlgn2-deficient mice [50]. The gene discussed is NLGN2; the disease is Anxiety.