We analyzed the association between serum H3Cit-DNA levels, double-stranded DNA, and classical inflammatory markers –such us interleukin (IL) 6 and 1β, TNF-α, and C-reactive protein (CRP)– on admission and the occurrence of major cardiovascular events (MACE), including death, reinfarction, urgent revascularization, or heart failure, after STEMI. Here, TNF is linked to heart failure.