PHLPP1 and neoplasm: To assess somatic mutations in either PHLPP1 or PHLPP2 associated with cancer, we plotted synonymous (silent) and nonsynonymous (missense) mutations reported in the Catalog of Somatic Mutations In Cancer (COSMIC) database (36) and compared them to two Cancer Gene Census (CGC) (35) tumor suppressor genes, two CGC oncogenes, and two randomly chosen olfactory receptor genes as negative controls (genes that are very unlikely to be functionally involved in cancer development).