PHLPP1 and cancer: To assess whether PHLPP1 or PHLPP2 is an essential gene in cancer cells, we plotted the gene effect score for 1,100 cancer cell lines reported in the Dependency Map (DepMap) Public 23Q4+Score (Chronos) CRISPR knockout screens (37, , –40), 710 cancer cell lines reported in the Achilles+DRIVE+Marcotte (DEMETER2) RNA interference (RNAi) knockdown screens (41, , –44), and 317 cancer cell lines reported in copy number effect-corrected (39) CRISPR knockout screens (SI Appendix, Fig. S7 A and B).