TCF7 and colorectal carcinoma: These genes were also enriched in NK cell populations mined from a published scRNA-seq dataset of liver metastasis from a cohort of patients with CRC, validating the translational relevance of this observation (32); we found higher frequency of NK_FCGR3A_CXCR4, NK_CXCR3 and NK_MKI67 clusters in LM compared with MFL (Figure 2A and Supplemental Figure 4A), as NK_CXCR3 was enriched in transcripts linked to immature states (i.e., CCR7, TCF7, IL7R and SELL), while NK_MKI67 was for genes associated with survival and proliferation (i.e., MYC, BCL2 and CD9).