A cross-sectional study including 806 participants, published in 2021, indicated that moderate alcohol consumption (≥ 1 times/week) may have a detrimental influence on cerebrospinal fluid (CSF) AD biomarkers (Aβ burden, Tau/Aβ, and PTau/Aβ ratios) compared to the light drinking (> 0 times/week and < 1 times/week) [29]. This evidence concerns the gene MAPT and Alzheimer disease.