Ikaros family zinc fingers (IKZFs) can form a trimeric complex with the RUNX1‐binding partner CBFβ, suggesting that RUNX1 and RUNX3 desensitize MM to lenalidomide via protection of IKZFs from degradation.[30]IRF4 orchestrates oncogenic transcription in MM. This evidence concerns the gene RUNX1 and Miyoshi myopathy.