NPM1 and acute myeloid leukemia: HoxBlinc, previously linked to early hematopoiesis, has been identified as a carcinogenic long noncoding RNA (lncRNA) that plays a crucial role in NPM1-mutant (NPM1c+) acute myeloid leukemia (AML) through interaction with and recruitment of its partner mixed-lineage leukemia protein 1 (MLL1) to the promoter regions of NPM1c+-specific genes, fostering H3K4me3 modifications and thereby activating gene transcription (8).