Additionally, Hi-C analysis revealed alterations in TADs in 961C cells, with 97 new TADs formed and 56 TADs decreased, many of which were enriched in genes involved in transcription regulation and leukemogenesis, suggesting a crucial role of HoxBlinc in mediating chromatin remodeling and promoting the activation of leukemic signatures in NUP98-PHF23–driven leukemia (Figure 1) (11). This evidence concerns the gene NUP98 and leukemia.