ACAT1 and non-small cell lung carcinoma: Loss of Acat1 in NSCLC cells impedes TLS and anti-tumor immunotherapy ACAT1 increases intratumoral oxidative stress by promoting mitochondrial hypersuccinylation Reduction of oxidative stress promotes B cell aggregation to build the TLS ACAT1 correlates with TLS abundance and immunotherapeutic response of NSCLC patients