Tumorigenesis was significantly faster in Acat1–/– mice compared with their Acat1+/+ counterparts (Supplemental Figure 2, C and D), whereas, in Rag1–/– mice without T and B lymphocytes, tumor development did not differ significantly between the NC and KD LLC groups (Supplemental Figure 2, E and F). Here, ACAT1 is linked to neoplasm.