PNPLA3 interacts strongly with insulin resistance to drive hepatic steatosis, and a combination of the PNPLA3 risk allele, insulin resistance, and their interaction explained 8% of the variation in hepatic steatosis in nondiabetic individuals, suggesting that many individuals at high risk of hepatic steatosis are not currently being treated (67). The gene discussed is PNPLA3; the disease is Hepatic steatosis.