Beyond its reproducible association with MASLD (15, 18, 25, 27–30, 32–35, 37–41), PNPLA3 I148M has been recognized as a risk factor for steatohepatitis, fibrosis/cirrhosis, and HCC (5, 25, 45–48). The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.