PNPLA3 and obesity due to melanocortin 4 receptor deficiency: For example, an individual with normal weight and minimal insulin resistance may have only a 10% increased risk of having hepatic steatosis based on the PNPLA3-rs738409-CG genotype (vs. CC genotype), whereas an individual with diabetes and obesity may experience a 50%–100% increase in risk from the same genotype.