Chen et al. found that individuals with PNPLA3 risk alleles who followed a Mediterranean-style diet or had high intake of fruits, vegetables, and legumes derived even more benefit in hepatic steatosis reduction attributable to these dietary patterns than those without the alleles; a PRS additionally interacted with fish intake to strengthen its protective effects against steatosis (71). This evidence concerns the gene PNPLA3 and steatosis.