TM6SF2 and liver disorder: Taking this approach, Verweij et al. (42) conducted gene-based tests for ALT, aspartate aminotransferase (AST), and liver diseases, and identified five suggestive genes, apolipoprotein B (APOB), ABCB4, SLC30A10, and TM6SF2, associated with increased liver disease, and cell death inducing DFFA like effector B (CIDEB), associated with decreased risk of liver disease.