The second documented case of a phenotypic shift in this direction is described by Al-Ibraheemi et al. of a 40-year-old female with PTCL who demonstrated a shift from CD4-/CD8+/TIA1+ to CD4+/CD8-/TIA1- [12]. Here, TIA1 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.