MAPT and early-onset autosomal dominant Alzheimer disease: The search covered studies published between 2011 and 2024 using predefined keywords and Medical Subject Headings (MeSH) terms, including "Alzheimer’s disease", "blood biomarkers", "β-amyloid", "phosphorylated tau" "p-Tau181", "p-Tau217", "p-Tau231", and "early diagnosis".