MAPT and Alzheimer disease: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science for studies published between 2011 and 2024. This review synthesizes findings from 33 peer-reviewed studies to evaluate the diagnostic and prognostic utility of these biomarkers. Results demonstrate that blood Aβ and p-Tau levels strongly correlate with cerebrospinal fluid (CSF) biomarkers and neuroimaging measures of AD pathology.