Moreover, short-chain fatty acids (SCFAs), which are the principal metabolites produced by microbial fermentation of indigestible carbohydrates, can directly reduce the expression of DNMT1, DNMT3a, and DNMT3b and inhibit their binding to the promoters of adiponectin and resistin, thereby correcting the abnormal expression of these molecules in obesity (Lu et al., 2018). Here, DNMT1 is linked to obesity due to melanocortin 4 receptor deficiency.