Yuan et al. (2022) conducted an association analysis involving 733 older Chinese individuals diagnosed with MASLD and 824 age- and race-matched controls. The variants rs780094 and rs1260326 of GCKR were found to be significantly associated with MASLD, with the T allele of rs1260326 correlating with elevated triglyceride levels. A GWAS involving 902 individuals with MASLD and 7,672 controls from the general population in Japan identified a significant association between the rs1260326 SNP in the GCKR gene and MASLD (Kawaguchi et al., 2018). The gene discussed is GCKR; the disease is metabolic dysfunction-associated steatotic liver disease.