Donati et al. (2016) discovered that the PNPLA3 variant rs2294918 (A>G), which encodes the PNPLA3 K434E substitution, reduces PNPLA3 expression and mitigates the impact of the I148M variant on susceptibility to hepatic steatosis and liver injury. The gene discussed is PNPLA3; the disease is Hepatic steatosis.