PNPLA3 and fatty liver disease: In a recent study, Chen et al. (2024) systematically estimated the effects on hepatic steatosis of dietary patterns alongside genetic variants including PNPLA3-rs738409-G, TM6SF2-rs58542926-T, a polygenic risk score (PRS) based on 16 variants, and their interactions among 21,619 participants from the UK Biobank (UKBB).