These to some degrees echoed with Nir Melamed's finding16that sFlt-1 and PlGF can effectively predict preterm preeclampsia among patients with chronic kidney disease, and Provendier's research17that sFlt-1/PlGF presented an area under the curve of 0.90 in prediction preeclampsia in women with preexisting diabetes during the third trimester. Here, PGF is linked to chronic kidney disease.